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DNA aptamer-mediated regulation of the hairpin ribozyme by human α-thrombin

✍ Scribed by S. Hani Najafi-Shoushtari; Michael Famulok

Book ID
116304201
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
436 KB
Volume
38
Category
Article
ISSN
1079-9796

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## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine