DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model

Murine dendritic cells transfected with

Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8+ and CD4+ T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity

✍ Sixun Yang; Carol E. Vervaert; James Burch; Jr.; James Grichnik; Hilliard F. Sei 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 196 KB 👁 2 views

Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposomemediated gene transfer to examine the ability of plasmid DNA encoding the human melanoma-associated antigen gp100 to elicit CD8 ؉ an