DNA analyses of XX and XX-hypospadiac males

✍ Scribed by Hironao Numabe; Shigeo Nagafuchi; Yutaka Nakahori; Takashi Tamura; Hiromichi Kiuchi; Mikio Namiki; Naoya Kohda; Yoshimitsu Fukushima; Hideki Fuse; Motoyasu Kusano; Takayuki Arai; Yutaka Matsuzaki; Keiko Fukutani; Koichiro Isurugi; Yoshikazu Kuroki; Tatsuro Ikeuchi; Masahiko Yoshida; Shigeru Minowada; Yasuo Nakagome

• Book ID: 104669428
• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 523 KB
• Volume: 90
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00220064

✦ Synopsis

Fourteen 46,XX "males" were analyzed by Southern blot hybridization with seventeen different Y chromosome-derived DNA probes and by the polymerase chain reaction for an additional two sites on the short arm of Y. Eight 46,XX males possessed various segments of the short arm of the Y chromosome, including the sex determining region. The detected segments ranged from the two most distal loci to nearly the entire length of the short arm, viz., 10 out of 11 loci. None of the eight patients had hypospadia. Five out of the six remaining cases had hypospadia and no Y sequence was detected, suggesting the presence of a causative difference between hypospadiac and non-hypospadiac groups.