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DNA Alterations in Lynch Syndrome || Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype

✍ Scribed by Vogelsang, Matjaž


Book ID
120393065
Publisher
Springer Netherlands
Year
2013
Weight
669 KB
Category
Article
ISBN
9400765975

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The DNA mismatch repair (MMR) pathway is essential in maintaining genomic stability through its role in DNA repair and the checkpoint response. Loss of DNA MMR underlies the hereditary cancer disease Lynch Syndrome (LS). Germline mutations in MSH2 account for approximately 40% of LS patients and of