## Inactivation of the Rb pathway in non-small cell lung carcinoma (NSCLC) occurs mostly through inactivation of the cyclin-dependent kinase inhibitor p16 INK4A and/or up-regulation of cyclin D1. In order to assess the frequency and the prognostic value of these abnormalities in NSCLC, immunohisto
✦ LIBER ✦
DNA alterations at proto-oncogene loci and their clinical significance in operable non-small cell lung cancer
✍ Scribed by Camille Hajj; Riad Akoum; Edward Bradley; François Paquin; Joseph Ayoub
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 678 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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To study the involvement of DNA mismatch repair genes in non-small cell lung cancer, matched normal and tumoral DNA samples from 31 patients were analyzed for both LOH and microsatellite instability with 34 markers at or linked to hMLH1 (3p21), hMSH2 (2p16), hMSH3 (5q11-q13), hMSH6 (2p16), hPMS1 (2q