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DNA adducts in rats and mice following exposure to [4-14C]-1,2-epoxy-3-butene and to [2,3-14C]-1,3-butadiene

✍ Scribed by Peter J Boogaard; Kees P de Kloe; Ewan D Booth; William P Watson


Book ID
113517037
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
229 KB
Volume
148
Category
Article
ISSN
0009-2797

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## Abstract The tissue distribution, elimination and covalent binding of 2,3‐^14^C‐ and 1‐^14^C‐acrylonitrile (VCN) were studied in male Spragueβ€”Dawley rats given an oral dose of 46.5 mg kg^βˆ’1^. Exhalation of unchanged VCN, ^14^CO~2~ and H^14^CN was monitored at selected intervals. Only 5% of the t