2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
โฆ LIBER โฆ
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
โ Scribed by Adrian J. Fretland; Uday S. Devanaboyina; Norma A. Nangju; Matthew A. Leff; Gong H. Xiao; Stephanie J. Webb; Mark A. Doll; David W. Hein
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 88 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1095-6670
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Indole-3-carbinol (I3C), a naturally occurring inhibitor of experimental carcinogenesis, was evaluated for its possible inhibitory effect on DNA-adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary mutagen, in female F344 rats. PhIP is a mammary carcinogen in female