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DNA adduct formation in relation to tumorigenesis in mice continuously administered aromatic amine carcinogens

✍ Scribed by F.A. Beland; N.F. Fullerton; M.M. Marques; W.B. Melchior Jr.; B.A. Smith; C. Poirier

Book ID
113251950
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
101 KB
Volume
234
Category
Article
ISSN
0165-1161

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We transduced mouse cytochrome P4501A2 DNA into NIH 3T3 cells by retrovirus-mediated gene transfer. The capacity of the transduced cytochrome P4501A2 for metabolic activation and DNA-carcinogen adduct formation of aromatic amine carcinogens was investigated. Clones of NIH 3T3 cells that constitutive