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DNA adduct formation in mice following treatment with used engine oil and identification of some of the major adducts by 32P-postlabelling

✍ Scribed by Carmichael, Paul L.; Ni Shé, Meadhbh; Hewer, Alan; Jacob, Jürgen; Grimmer, Gernot; Phillips, David H.

Book ID
121782241
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
812 KB
Volume
64
Category
Article
ISSN
0304-3835

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## Abstract There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens in laboratory animals and are suspected human carcinogens. The PAHs are bioactivated by cytochrome P450 (CYP)1A1/1B1 enzymes to reactive intermediates that bind to DNA, a