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DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells

✍ Scribed by Jitka Poljaková; Eva Frei; Jacobo E. Gomez; Dagmar Aimová; Tomáš Eckschlager; Jan Hraběta; Marie Stiborová


Book ID
116334387
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
399 KB
Volume
252
Category
Article
ISSN
0304-3835

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DNA adduct formation by the anticancer d
✍ Marie Stiborová; Andrea Breuer; Dagmar Aimová; Martina Stiborová-Rupertová; Manf 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 161 KB

## Abstract Ellipticine is a potent antineoplastic agent whose mode of action is considered to be based mainly on DNA intercalation and/or inhibition of topoisomerase II. Recently, we found that ellipticine also forms covalent DNA adducts __in vitro__ and that the formation of the major adduct is d