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DNA adduct accumulation during the course of human cervical cancer development, and during and after radiotherapy

✍ Scribed by Ramesh Gupta; Radha Munagala; Manicka Vadhanam; Bala Nagarajan; Srivani Ravoori

Book ID
119380939
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
50 KB
Volume
189
Category
Article
ISSN
0378-4274

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## Abstract Loss of heterozygosity (LOH) is one of the most important mechanisms for inactivation of tumor‐suppressor genes. Studies of LOH in patients with cervical carcinoma have reported a high frequency of LOH on 3p21.3, 6p21.2, 17p13.1, and 18q21.2. Our study explored whether __p53__ status, h