Design, synthesis and evaluation of a no
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Christopher McGuigan; Karolina Madela; Mohamed Aljarah; Arnaud Gilles; Andrea Br
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Article
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2010
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Elsevier Science
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English
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We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of the guanine nucleoside. Modification of the ester an