DMF as a dimethylamine equivalent in the palladium-catalyzed nucleophilic substitution of naphthylmethyl and allyl acetates

✍ Scribed by Martial Toffano; Jean-Yves Legros; Jean-Claude Fiaud

• Book ID: 104255970
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 206 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02219-8

✦ Synopsis

Naphthylmethyl acetates la and 2a were substituted by morpholine in DMPU in the presence of 2 tool% of [Pd(dba)2 + 1.5 dppe] to give products 9-10 in 66-70% isolatea yield. In DMF in the presence of benzylamine, N.N.dimethylnaphthylmethylamines 11.12 were produced in 78-85% isolated yield.