Diversity-oriented pyrazol-3-one synthesis based on hydrazinodipeptide-like units prepared via the Ugi reaction

✍ Scribed by Ekaterina Lakontseva; Mikhail Krasavin

• Book ID: 104097909
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 501 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.05.133

✦ Synopsis

a b s t r a c t N-Cyanoacetyl-N 0 -trifluoroacetyl-N 0 -alkylhydrazines, prepared via hydrazino-Ugi reaction, provided different pyrazol-3-ones when exposed to mildly acidic and mildly basic conditions at 60 °C. These approaches offer a facile access to two different pyrazol-3-one-containing chemotypes in a diversity-oriented fashion, in only two chemical operations from simple precursors.