Diversity of germ-line immunoglobulin VH genes
β Scribed by Givol, David; Zakut, Rina; Effron, Kim; Rechavi, Gideon; Ram, Daniela; Cohen, Justus B.
- Book ID
- 109723647
- Publisher
- Nature Publishing Group
- Year
- 1981
- Tongue
- English
- Weight
- 562 KB
- Volume
- 292
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/292426a0
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The polymorphic nature of the immunoglobulin VH genes was investigated by Southern blot analysis of liver DNA of sixteen different mouse strains and hybridization with VH probes. Differences in restriction enzyme pattern (REP) were observed and six different patterns of restriction fragments were fo
Recent priilein eirul s,ene irijiieriee.i .show thai diversity in !innninogli)hiiliri ninable genes is generate// h\ mii/ti/ile aermline genes nhieh then nnilerga umiatie rearrangement nnil hyperrmilatiDn. An animal can produce an estimated 1(}"-10" unique antibodies'. One goal in molecular immunol