𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Diversification and progression of malignant tumors

✍ Scribed by Garth L. Nicolson; Nancy L. Rosenberg

Book ID
102760322
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
641 KB
Volume
6
Category
Article
ISSN
0265-9247

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✦ Synopsis

Tumor-cell diversification mechanisms insure that malignant neoplasms contain diversijied tumor-cell subpopulations. Because of the instability of tumor cell phenotypes, some malignant cells will evolve with the most favorable properties for their progression to highly metastatic cells. The rates of cellular phenotypic diversijication vary greatly among different tumors, and they are probably modulated, in part, by genetic and chromosome defects and by epigenetic events that may vary widely depending upon the nature of the tumor cells and their microenvironments. As tumor diversijication and selection proceed, the most malignant cell subpopulations may eventually become dominant and gradually lose their microenvironmental responsiveness. Tumor-cell diversijication mechanisms may be similar or identical to normal, developmentally regulated diversijication mechanisms that are used during embryonic cell diversijication and differen tiat ion.

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