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Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques

✍ Scribed by Stephen R. Walsh; Jacqueline Gillis; Björn Peters; Bianca R. Mothé; John Sidney; Alessandro Sette; R. Paul Johnson


Book ID
116961684
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
433 KB
Volume
27
Category
Article
ISSN
0264-410X

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Background: Until recently, there were no CD3 antibodies that crossreacted with rhesus macaque T cells. Consequently, studies relying on CD8 counts or CD4/CD8 ratios enumerated this subpopulation on the basis of CD8ϩ or CD8brightϩ staining. We used a rhesus-specific, anti-CD3 antibody to better defi