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Diverse characteristics of111In labelled anti-CEA monoclonal antibodies for tumour immunoscintigraphy: Radiolabelling, biodistribution and imaging studies in mice with human tumour xenografts

โœ Scribed by Malcolm V. Pimm; Alan C. Perkins; Robert W. Baldwin


Publisher
Springer
Year
1987
Tongue
English
Weight
797 KB
Volume
12
Category
Article
ISSN
0340-6997

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Comparative biodistributions and rates o
โœ M. V. Pimm; R. W. Baldwin ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 555 KB

The rate of catabolism of a radiolabelled monoclonal anti-CEA antibody has been compared with that of control IgG1 in control nude mice and in mice with CEA producing xenografts and antigen negative xenografts. The rate of catabolism of antibody, but not of IgG, was increased 3-4 fold in mice with x