Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells

Activation of the α2β1 integrin-mediated

Activation of the α2β1 integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells by shifts in the concentrations of extracellular Mg2+ and Ca2+

✍ John J. Grzesiak; Michael Bouvet 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 755 KB

## Abstract The authors have previously demonstrated that α~2~β~1~ integrin‐mediated pancreatic cancer cell adhesion to Type I collagen is Mg^2+^‐dependent, inhibited by Ca^2+^, and that this integrin, purified from cell lysates using Type I‐collagen‐sepharose in Mg^2+^, can be eluted with Ca^2+^.