Diurnal variation of nicotine-induced ACTH and cortisol secretion in non-smoking healthy male volunteers
✍ Scribed by Jogin H. Thakore; Carlo Berti; Timothy G. Dinan
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 93 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
Most investigators have used either cigarette smoking or intravenous nicotine in order to try and study the eects of nicotine exposure on the hypothalamic±pituitary±adrenal (HPA) axis in man. Our two aims in this study were, ®rstly, to try and determine the eects of intra-nasal nicotine on the HPA axis and, secondly, to see whether these eects were time-dependent. Six male non-smoking subjects were given either placebo or 1 . 0 mg of intranasal nicotine at 0900 h and at 1700 h. A one way analysis of variance and post hoc tests revealed signi®cantly greater nicotine versus placebo-induced D cortisol values at 1700 h and at 0900 h (F 4 . 004, df 3, p 5 0 . 02). A one way analysis of variance and post hoc tests revealed that nicotine versus placebo-induced D ACTH values were signi®cantly greater at both the 0900 h (p 5 0 . 05) and 1700 h test sessions (p 5 0 . 05); furthermore, nicotine-induced D ACTH values were signi®cantly higher at 1700 h than at 0900 h (p 5 0 . 05) (F 199 . 04, df 3, p 5 0 . 0002). We have found that intra-nasal nicotine is capable of stimulating the HPA axis and, furthermore, this activation is time dependent.