Diuretics and carbohydrate metabolism: The effects of furosemide and amiloride on blood glucose, plasma insulin and cations in the rat
β Scribed by A. Aynsley-Green; K. G. Alberti
- Publisher
- Springer
- Year
- 1973
- Tongue
- English
- Weight
- 820 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0012-186X
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π SIMILAR VOLUMES
The diuretic furosemide (0.5 mmol/l) impaired glucose uptake in the soleus muscle of the rat by decreasing the sensitivity of glycolysis to insulin. In addition, at higher concentrations (1.0 mmol/l) the drug inhibited the basal rate of glycolysis. It did not, however, inhibit the rate of glycogen s
Insulin 0.05 mu/kg body weight was injected intravenously into 14 subjects both at 8 a.m. and 5 p.m. in random order 12 hrs after a 50 g glucose meal. Fasting glucose levels were similar in both cases but the 48percent plus or minus 10 percent fall in blood glucose in the morning was significantly g