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Dithiocarbamate analog N-(4-methoxybenzyl)-N-dithiocarboxy-D-glucamine reduces the retention of ingested cadmium in rats

✍ Scribed by B. Kargačin; K. Kostial; R. Arežina; P. K. Singh; M. M. Jones; M. Cikrt

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
244 KB
Volume
11
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

This study was performed to evaluate the effect of oral and intraperitoneal treatment with N‐(4‐methoxybenzyl) D‐glucamine dithiocarbamate monohydrate (MeOBDCG) after a single oral administration of ^115m^Cd to 6‐week‐old rats. Oral treatment reduced the retention of ^115m^Cd in the whole body, gut, liver and kidney by 5, 3, 4 and 3 times respectively, and intraperitoneal treatment reduced the retention by 7,2.5, 16 and 4.5 times, respectively. This finding is new, since it was believed that oral dithiocarbamate treatment would increase the toxicity and absorption of ingested cadmium.

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Organ cadmium deposits in orally exposed
Organ cadmium deposits in orally exposed female rats and their pups and the depleting efficiency of sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate monohydrate (MeOBDCG)
✍ K. Kostial; M. Blanuša; N. Schönwald; R. Arežina; M. Piasek; M. M. Jones; P. K. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB

Cadmium was given to female rats in the drinking water (50 ppm Cd) from 4 weeks before mating until weaning (a total of 10 weeks). Four weeks after the discontinuation of exposure, mothers and offspring were then given two i.p. doses of 1 mmol kg-' sodium N-(4-methoxybenzyl)-~-glucamine-N-carbodithi