✦ LIBER ✦
Dithio- und Thionester, 55. Synthese vonN-geschützten, optisch aktiven α-Aminothionsäureestern
✍ Scribed by Brutsche, Andreas ;Hartke, Klaus
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 481 KB
- Volume
- 1992
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Dithio and Thiono Esters, 55. — Synthesis of N‐Protected, Optically Active α‐Amino Thiono Esters
The N‐protected α‐amino amides 1 are O‐alkylated with trialkyloxonium tetrafluoroborates to form the iminium salts 2. Sulfhydrolysis of 2 yields the α‐amino thiono esters 3. This reaction sequence allows the preparation of enantiomerically pure 3.