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Diterpenoids from the Hainan Soft Coral Sinularia parva

✍ Scribed by Yan Li; An-Hui Gao; Hui Huang; Jia Li; Ernesto Mollo; Margherita Gavagnin; Guido Cimino; Yu-Cheng Gu; Yue-Wei Guo

Publisher: John Wiley and Sons
Year: 2009
Tongue: German
Weight: 282 KB
Volume: 92
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200800447

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✦ Synopsis

Abstract

Two new cembrane diterpenes, sinulaparvalides A and B (1 and 2, resp.), which contain an intriguing seven‐membered lactone moiety, along with the four known related cembranoids 3–6, were isolated from the Hainan soft coral Sinularia parva. The structures of compounds 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D‐NMR techniques, and were confirmed by single‐crystal X‐ray diffraction analysis. The in vitro cytotoxic activities of these compounds were tested on human colon carcinoma (HCT‐116), human promyelocytic leukemia (HL‐60), and human lung carcinoma (A‐549) tumor cell lines.

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