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Diterpenoids from Isodon pharicus

✍ Scribed by Yong Zhao; Sheng-Xiong Huang; Wei-Lie Xiao; Li-Sheng Ding; Jian-Xin Pu; Xian Li; Li-Bin Yang; Han-Dong Sun

Book ID: 104096313
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 367 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.02.102

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✦ Synopsis

A phytochemical investigation of Isodon pharicus led to the isolation of a novel asymmetric ent-kauranoid dimer, bispseurata F (1), and three new diterpenoids, pharicinins A-C (2-4). Their structures were elucidated by extensive spectroscopic analysis. Compound 1 features a unique linkage pattern of C-17 with C-11 0 to connect the two monomers. A possible biogenetic pathway of 1 was also proposed. Compounds 3 and 4 exhibited moderate inhibitory activity against NB4 and SH-SY5Y cell lines.

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