Disulfide Core Cross-Linked PEGylated Polypeptide Nanogel Prepared by a One-Step Ring Opening Copolymerization of N-Carboxyanhydrides for Drug Delivery
✍ Scribed by Tao Xing; Bin Lai; Xiaodong Ye; Lifeng Yan
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 575 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A novel disulfide core cross‐linked PEGylated polypeptide nanogel has been synthesized by a one‐step ring opening copolymerization of γ‐benzyl L‐glutamate N‐carboxyanhydride and L‐cystine N‐carboxyanhydride using an amino group‐terminated poly(ethylene glycol) methyl ether as initiator. Characterization of products confirms the formation of a core cross‐linked PEGylated nanogel with disulfide linkages with a size of about 250 nm, and these studies also confirm that this nanogel can easily be broken by glutathione. Cell viability experiments show the good biocompatibility of the as‐prepared polymer. Studies relating to loading and controlled release of indomethacin under reduction‐sensitive conditions reveal that the nanogel is a good candidate for drug delivery systems.
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