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Disulfide arrangement of human insulin-like growth factor I derived from yeast and plasma

✍ Scribed by Kent AXELSSON; Stig JOHANSSON; Gunilla EKETORP; Henric ZAZZI; Barbro HEMMENDORF; Pär GELLERFORS


Book ID
115129382
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
710 KB
Volume
206
Category
Article
ISSN
1432-1327

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Probing the disulfide folding pathway of
✍ Steven J. Milner; John A. Carver; F. John Ballard; Geoffrey L. Francis 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB 👁 1 views

The crucial step of folding of recombinant proteins presents serious challenges to obtaining the native structure. This problem is exemplified by insulin-like growth factor (IGF)-I which when refolded in vitro produces the native three-disulfide structure, an alternative structure with mispaired dis