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Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos

โœ Scribed by V. I. Kukharenko; A. A. Delvig; K. N. Grinberg

Book ID
104767368
Publisher
Springer
Year
1984
Tongue
English
Weight
248 KB
Volume
68
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased.

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## Abstract Using collagenase digestion as an assay for collagen in partially synchronized secondary cultures of chick embryo fibroblasts, we find that the rate of collagen synthesis remains at a constant fraction of overall protein synthesis (5%) regardless of the growth rate of the cells even whe