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Distribution of γ-aminobutyric acid and other amino acids in nervous tissue of various species

✍ Scribed by Roberts, Eugene ;Lowe, Irene P. ;Guth, Lloyd ;Jelinek, Bohdan

Publisher
John Wiley and Sons
Year
1958
Tongue
English
Weight
873 KB
Volume
138
Category
Article
ISSN
0022-104X

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✦ Synopsis

Introduction

y-Aminobutyric acid (GABA) has been found in an easily extractable form in large amounts in the brain and spinal cord of various species of animals. This amino acid and the enzyme which catalyzes its formation from L-glutamic acid, L-glutamic acid decarboxylase, are present in uniquely high concentrations in the tissue of the central nervous system. Studies on the gross localization of the glutamic acid decarbouylase-GABA system were consistent with the interpretation that it is mainly operative in the central nervous system, probably chiefly in the gray matter (see Roberts, '56 for pertinent literature). Recent results obtained with ultramicrochemical procedures which allow a fine degree of localization also have shown that the glutamic decarboxylase activity is found

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