Distribution of β-human chorionic gonadotropin-positive cells in noncancerous gastric mucosa and in malignant gastric tumors
✍ Scribed by Yoichi Yakeishi; Masaki Mori; Munetomo Enjoji
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 781 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
The authors examined the localization and behavior of &human chorionic gonadotropin (HCG)-positive cells in human gastric noncancerous mucosa and in gastric malignant tumors, using immunohistochemistry and the anti-B-HCG antibody. The j3-HCG-positive cells were located mainly in the antral mucosa and were generally restricted to the neck portion of the pyloric glands, although a few were present in fundic glands of the gastric body. The /3-HCG-immunoreactive cells were found in gastric carcinomas in 53% of the 92 cases examined. These cells were observed more often in advanced carcinomas that were histologically poorly differentiated than in early carcinomas or in well-differentiated tumors, but this prevalence had no statistical significance. The presence of the 8-HCG-positive cells in the gastric carcinomas suggested no appreciable prognostic significance, even quantitatively. In the syncytiotrophoblast-like tumor cells seen in four gastric tumor samples with histologic features of a choriocarcinoma, immunoreactivity to the 8-HCG was striking. There was, however, no recognizable dominance in the number of 8-HCG-reactive cells in the noncancerous mucosa around the tumor. Cancer 66:695-701.1990.
UMAN CHORIONIC GONADOTROPIN (HCG) is a gly-H coprotein hormone consisting of two subunits: a and P. The a-subunit is nearly identical in chemical structure to other glycoprotein hormones such as human luteinizing (HLH), human follicle-stimulating, and human thyroid-stimulating hormones.' On the other hand, the P-subunits are unique in that they have biologic specificity for each hormone mentioned above.2 The HCG is secreted by syncytiotrophoblasts of the placenta and in increased amounts by neoplastic cells in tumors of trophoblastic rigi in.^.^ This hormone can be secreted by various of nontrophoblastic neoplasm^,^-^ and HCG-immunoreactive cells have been identified in different noncancerous tissues of the gastrointestinal tract. ''-I2 The distribution