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Distribution of spontaneous chromosome breaks in human chromosomes

✍ Scribed by Pertti Aula; Harriet Koskull

Publisher
Springer
Year
1976
Tongue
English
Weight
679 KB
Volume
32
Category
Article
ISSN
0340-6717

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✦ Synopsis

Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.

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