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Distribution of PON1 polymorphisms—PON1Q192R and PON1L55M among Chinese, Malay and Indian males in Singapore and possible susceptibility to organophosphate exposure

✍ Scribed by Sin Eng Chia; Safiyya Mohamed Ali; Peng Huat Eric Yap; Linda Gan; Yeong Bing Ong; Kee Seng Chia

Book ID
116780018
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
215 KB
Volume
30
Category
Article
ISSN
0161-813X

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## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o