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Distribution of intact and Fab12fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts

✍ Scribed by Frances Searle; Theresa Adam; Joan A. Boden

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
549 KB
Volume
21
Category
Article
ISSN
0340-7004

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✦ Synopsis

A direct comparative study of the distribution of intact and Fab~ fragments of mouse monoclonal antihuman chorionic gonadotrophin antibody, WI4A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.

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