Distribution of dibenzoxazepines bearing the carboxamide or other side chains in ocular and other tissues of dogs
✍ Scribed by Jacques Dreyfuss; James M. Shaw; John J. Ross Jr; Geng Mei Wang; Keith K. Wong; Eric C. Schreiber
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 451 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
I J The distribution of four substituted dibenzoxazepines in tissues of dogs was examined 7-14 days after oral administration to intact dogs and 7 hr. after intravenous administration to dogs with externalized bile ducts. 4-[3-(7-Chloro-5,1 I-dihydrodibenz-[b,c][ 1,4]oxazepin-5-yl)propyl]-1 -piperafine ethanol hydrochloride, its trifluoromethyl analog, and 5~(2-dimethylamino)ethy1]-5,11dihydrodiben@,e][ I ,410xazepine maleate were present in organs in greater concentrations than in blood, particularly in the brain, liver, lungs, and melanin-containing portion of the eye consisting of the combined retina, choroid, and sclera. These same compounds were bound to various extents to melanin granules of beef eyeball in cirro. FChloro-5, I I-dihydrodibenz[b,e][ I ,4]oxazepine-5-carboxamide, which bears a carboxamide substituent, was neither localized in any tissues of dogs, relative to concentrations in blood, nor bound to melanin granules in airro. It is concluded that the presence of the carboxamide side chain alters the affinity of 7chloro-5,lldihydrodibeni$b,~~][l,4]oxazepine-5-carboxamide for tissues, especially those containing melanin.
Keyphrases 0 Dibenzoxazepines, carboxamide and other side chains-tissue distribution, affinity for melanin, dogs 0 Carboxamide-substituted dibenzoxazepines-tissue distribution in dogs, affinity for melanin 0 Tissue distribution-dibenzoxazepines, melanin affinity, dogs 0 Melanin tissue distribution-dibenzoxazepines, dogs 0 Ocular tissue distribution-dibenzoxazepines, dogs