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Distribution of body water in patients with cirrhosis: The effect of liver transplantation

✍ Scribed by Dr. Darrell H. G. Crawford; June W. Halliday; W. G. E. Cooksley; Therese L. Murphy; Suzanne D. Golding; Jennifer D. Wallace; Ross C. Cuneo; Steven V. Lynch; Russell J. Strong; Lawrie W. Powell

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 647 KB
Volume: 17
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840170612

No coin nor oath required. For personal study only.

✦ Synopsis

We compared total body water and intracellularextracellular distribution of body water between male patients with mild liver disease without ascites (n = 9), male patients with severe liver disease and gross ascites (n = 6) and a group of age-, sex-, height-and weight-matched controls (n = 6). In addition, we documented the effects of liver transplantation on intracellular, extracellular and total body water in 12 patients (6 men and 6 women) by means of deuterium oxide dilution and whole-body potassium counting. We saw no significant difference in total body water between the healthy controls, patients without ascites and patients with ascites (46.5 f 9.2 kg, 45.4 f 6.6 kg and 50.4 f 5.1 kg, respectively), although, as expected, extracellular water was increased in patients with ascites compared with healthy controls and cirrhotic patients without ascites (36.9 2 6.5 kgvs. 25.4 2 4.4 kg, p = 0.005;and36.9 f 6.5kgvs.27.0 f 5.3kg,p = 0.002, respectively). We found no difference between nonascitic patients and healthy controls (25.4 f 4.4 kg vs. 27.0 2 5.3 kg). However, intracellular water was significantly reduced in patients with severe liver disease compared with that in controls (13.6 f 3.3 kg vs. 21.5 f 4.2 kg, p = 0.005) or patients without ascites (13.6 f 3.3 kgvs. 18.3 f 2.9 kg,p = 0.01). Thereduction of intracellular water appears to be due to loss of body cell mass. The mean body weight of the group of patients who were studied before and 3 mo after liver transplantation did not change (69.0 f 10.2 kg vs. 69.0 f 11.1 kg), but we noted significant decreases in mean total body water and mean extracellular water (43.5 f 9.0 kg vs. 40.5 7.6 kg, p = 0.02; and 27.8 2

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