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Distribution of BK polyomavirus genotypes in Tunisian renal transplant recipients

✍ Scribed by Hanen Boukoum; Imen Nahdi; Vincent Foulongne; Dorsaf Zallema; Sabra Aloui; Abdelatif Achour; Michel Segondy; Mahjoub Aouni

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 128 KB
Volume: 83
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.22035

No coin nor oath required. For personal study only.

✦ Synopsis

BK polyomavirus (BKV) is a ubiquitous virus in humans that remains latent in the urogenital tract after a primary infection during childhood. The virus, which is reactivated frequently and excreted in urine, can cause nephropathy in renal transplant recipients. BKV sequences are classified into four subtypes (I-IV). Subtype I and IV are divided further into four and six subgroups, respectively. To characterize the subtypes of BKV prevalent in Tunisia, the presence of the virus was investigated by real-time PCR in urine samples from 77 renal transplant recipients. For subtype identification, a DNA fragment in the VP1 coding region, amplified by nested PCR from positive samples, was sequenced and a phylogenetic analysis was performed. In the studied population, subtype I (75.5%), II (14.5%), and IV (2.5%) were identified with a clear predominance of subtype Ib-2 (73%) as observed in European population. This study suggests that in North Africa, the BKV genotype distribution is similar to that of Europe and different from that of sub-Saharan Africa.

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