Photodynamic therapy and photodynamic diagnosis help to support efficient treatment of superficial and early-stage cancer. During the last few years, 5-aminolevulinic acid (5-ALA), a precursor of haemoglobin in the haem biosynthetic pathway, was used to stimulate endogenous porphyrin production. In
Distribution of 5-aminolevulinic acid derivatives and induced porphyrin kinetics in mice tissues
✍ Scribed by Gabriela Di Venosa; Alcira Batlle; Haydée Fukuda; Alexander MacRobert; Adriana Casas
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 305 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0344-5704
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The accumulation of endogenous porphyrins in rats following systemic administration of 5-aminolaevulinic acid (ALA) has been examined to assess the photosensitization characteristics of this technique for photodynamic therapy (PDT) and chemical extraction assays with fluorescence and absorbance dete