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Distribution Coefficients by Curve Fitting: Application to Ionogenic Nonsteroidal Antiinflammatory Drugs

✍ Scribed by Barbato, F. ;Caliendo, G. ;La Rotonda, M. I. ;Silipo, C. ;Toraldo, G. ;Vittoria, A.

Book ID: 112185211
Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 708 KB
Volume: 5
Category: Article
ISSN: 1611-020X
DOI: 10.1002/qsar.19860050303

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Ionization constants by curve fitting: Application to the determination of partition coefficients

✍ Frank H. Clarke 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 562 KB

A multiparametric curve-fitting technique for pK, calculation has been adapted for use with a programmable calculator or microcomputer. This method provides for the convenient and accurate determination of the ionization constant in aqueous solution and of the apparent ionization constant in the pre