Distribution and retention of benzo(a)pyrene in rats after inhalation
โ Scribed by Mitchell, C.E.
- Book ID
- 120461161
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 538 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0378-4274
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๐ SIMILAR VOLUMES
Eight pregnant rats were exposed, on the 17th day of gestation, for 95 min to a microcondensation aerosol of benzo[a]pyrene at five different atmospheric concentrations between 200 and 800 mg m-3 in a 'head-only' inhalation chamber. Five rats were killed immediately following the exposure and three
3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a