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Distribution and disposition of benzalkonium chloride following various routes of administration in rats

✍ Scribed by Yuying Xue; Yoko Hieda; Yoji Saito; Takeshi Nomura; Junko Fujihara; Koji Takayama; Kojiro Kimura; Haruo Takeshita


Book ID
119377841
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
347 KB
Volume
148
Category
Article
ISSN
0378-4274

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The effects of the spermicide benzalkonium chloride (BKC) were studied on the conceptus of rat. Single doses (0, 25, 50, 100 or 200 mg kg-') of aqueous solutions of BKC were administered intravaginally (1 ml kg-I) on gestational day 1. The vulval metallic clips, used to prevent leakage of the soluti