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Distribution and development of glutamine synthetase in the embryonic cerebral hemisphere

✍ Scribed by Piddington, R.

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
622 KB
Volume
177
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Glutamine synthetase (GS) activity is preferentially localized in a distinct cell mass, the ectostriatum, in cerebral hemispheres of late chick embryos. GS activities rise in the ectostriatum coincident with the growth of this prominent nucleus. GS development in the ectostriatum may be controlled by normal increases of 11β‐hydroxyl corticosteroids in late embryonic serum. It is clear in any case that GS activities in this area of the hemisphere are susceptible to precocious induction by these steroids in vitro. The significance of GS localization in the ectostriatum is discussed in terms of the possible normal roles for this enzyme in nervous tissue.

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