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Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies

โœ Scribed by L.G Kirby; L Pernar; R.J Valentino; S.G Beck

Book ID
117490818
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
630 KB
Volume
116
Category
Article
ISSN
0306-4522

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YM992 is a selective serotonin (5-HT) reuptake inhibitor and a 5-HT 2A antagonist with potential antidepressant activity. As expected from a 5-HT reuptake inhibitor, which induces an accumulation of 5-HT in the dorsal raphe, YM992 inhibited the firing activity of these 5-HT neurons (ED50: 2.0 ฯฎ 0.2