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Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis

✍ Scribed by Hiroshima, Kenzo; Iyoda, Akira; Shida, Takashi; Shibuya, Kiyoshi; Iizasa, Toshihiko; Kishi, Hirohisa; Tanizawa, Tohru; Fujisawa, Takehiko; Nakatani, Yukio


Book ID
109888482
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
317 KB
Volume
19
Category
Article
ISSN
0893-3952

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BACKGROUND. The classification of pulmonary neuroendocrine neoplasms is particularly controversial. Large cell neuroendocrine carcinoma (LCNEC) has emerged as a separate entity among pulmonary endocrine neoplasms and the criteria for its histologic diagnosis are now well-described. However, cytologi