To elucidate the cellular role of BRCA2 in sporadic breast tumors, we studied the cellular localization and the expression of BRCA2 in carcinomas presenting or not allelic loss of BRCA2. The breast tumors were first classified with or without allelic loss of BRCA2 and then immunohistochemical staini
Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1p
β Scribed by Mukasa, Akitake; Ueki, Keisuke; Matsumoto, Shinichi; Tsutsumi, Shuichi; Nishikawa, Ryo; Fujimaki, Takamitsu; Asai, Akio; Kirino, Takaaki; Aburatani, Hiroyuki
- Book ID
- 110066685
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 338 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Loss of heterozygosity (LOH) on chromosomal arms 1p and 19q is the most common genetic alteration in oligodendroglial tumors and associated with response to radioβ and chemotherapy as well as favorable prognosis. Using microsatellite analysis, we previously identified the chromosomal re
Cigarette smoking is the major known risk factor for head and neck cancer. Tobacco promotes oxidative stress and enhances tissue levels of 8-hydroxyguanine (8-OH-G) in smokers. The presence of 8-OH-G does not impede replication but leads to an accumulation of G 3 T transversions. Recently, the gene