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Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors

✍ Scribed by P M L Vanderheyden; F L P Fierens; J P De Backer; N Fraeyman; G Vauquelin

Book ID: 110004151
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 367 KB
Volume: 126
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0702398

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon