✦ LIBER ✦

DISTINCT, VERY HIGH FREQUENCY OSCILLATIONS IN THE ACTIVITY AND AMOUNT OF ACTIVE ISOZYME OF LACTATE DEHYDROGENASE IN MURINE ERYTHROLEUKAEMIC CELLS AND A CELL-FREE SYSTEM

✍ Scribed by G.M.N. FERREIRA; K.D. HAMMOND; D.A. GILBERT

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 347 KB
Volume: 20
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1996.0082

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✦ Synopsis

Electrophoretic and kinetic determinations of the activity of lactate dehydrogenase in murine erythroleukaemic (MEL) cells, sampled at 1 min intervals, reveal distinct oscillations in the activity and amount of active isozyme. Both oscillations have periods in the range of 2-6 min (probably less) and both appear to be rhythmically modulated with respect to period, amplitude and mean. The oscillations also occur in cell-free systems, a fact which throws doubt on the value of studies where it is assumed that such preparations have constant composition.

1996 Academic Press Limited K: oscillations; lactate dehydrogenase; isozyme; murine erythroleukaemia.

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