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Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

✍ Scribed by Hugues, Stéphanie; Fetler, Luc; Bonifaz, Laura; Helft, Julie; Amblard, François; Amigorena, Sebastian

Book ID
109922003
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
561 KB
Volume
5
Category
Article
ISSN
1529-2908

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## Abstract Steady‐state dendritic cells (DC) present peptide‐MHC complexes to T cells in a tolerogenic manner, presumably because of deficient costimulation. However, it is clear that the path to tolerance involves initial T cell activation, suggesting that the deficit may lie in late‐acting costi