Distinct roles of doublecortin modulating the microtubule cytoskeleton
✍ Scribed by Moores, Carolyn A; Perderiset, Mylène; Kappeler, Caroline; Kain, Susan; Drummond, Douglas; Perkins, Stephen J; Chelly, Jamel; Cross, Rob; Houdusse, Anne; Francis, Fiona
- Book ID
- 110031717
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 402 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0261-4189
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Doublecortin (DCX) plays an important role in neuronal migration and development, and the participation of DCX in neuronal migration has been demonstrated by intensive mutational analysis for patients with X-linked or sporadic lissencephaly, and/or subcortical laminar heterotopia. Although a previou
Microtubules are specifically and efficiently visualized with the new fluorescent taxoids 7-O-[N-(4'-fluoresceincarbonyl)-L-alanyl]taxol (FLUTAX) and 7-O-[N-(4'-tetramethylrhodaminecarbonyl)-L-alanyl]taxol (ROTAX). Similarly to taxol, FLUTAX and ROTAX are able to drive inactive GDP-liganded tubulin