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Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts

โœ Scribed by Tomoyuki Fukui; Kazumi Yamauchi; Taketo Muroya; Masahiro Akiyama; Hisaji Maki; Akio Sugino; Shou Waga


Book ID
108589754
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
387 KB
Volume
9
Category
Article
ISSN
1356-9597

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We have used Xenopus egg extracts to investigate the effects of the antitumor drug daunomycin on DNA replication in vitro. Xenopus sperm nuclei replicated nearly synchronously in our egg extracts, thereby allowing us to determine the effects of the drug on both replication initiation and elongation.