Daunomycin disrupts nuclear assembly and
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Fenfei Leng; Gregory H. Leno
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Article
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1997
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John Wiley and Sons
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English
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๐ 2 views
We have used Xenopus egg extracts to investigate the effects of the antitumor drug daunomycin on DNA replication in vitro. Xenopus sperm nuclei replicated nearly synchronously in our egg extracts, thereby allowing us to determine the effects of the drug on both replication initiation and elongation.