Distinct roles for Sp1 and E2F sites in
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David E. Jensen; Adrian R. Black; Andrew G. Swick; Jane Clifford Azizkhan
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Article
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1997
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John Wiley and Sons
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English
β 100 KB
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Dihydrofolate reductase activity is required for many biosynthetic pathways including nucleotide synthesis. Its expression is therefore central to cellular growth, and it has become a key target for cancer chemotherapy. Transcription of the dihydrofolate reductase gene is regulated with growth, bein